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SS-31 10MG

SS-31 10MG

$60.00

SS-31 SS-31 (Elamipretide) is a synthetic mitochondria-targeting tetrapeptide designed to concentrate in the inner mitochondrial membrane. Preclinical studies in cell cultures and animal models indicate that SS-31 binds to cardiolipin, stabilizes mitochondrial cristae, reduces reactive oxygen species production, and protects against oxidative damage in various tissues.[1][2] Key Research Areas Mitochondrial Protection & ROS Reduction –…

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SS-31

SS-31 (Elamipretide) is a synthetic mitochondria-targeting tetrapeptide designed to concentrate in the inner mitochondrial membrane. Preclinical studies in cell cultures and animal models indicate that SS-31 binds to cardiolipin, stabilizes mitochondrial cristae, reduces reactive oxygen species production, and protects against oxidative damage in various tissues.[1][2]

Key Research Areas

  • Mitochondrial Protection & ROS Reduction – In rodent models of ischemia-reperfusion injury and neurodegenerative conditions, SS-31 has been shown to decrease mitochondrial ROS generation, prevent cardiolipin peroxidation, and preserve mitochondrial membrane potential.[3][4]
  • Cardiac & Skeletal Muscle Function – Preclinical investigations demonstrate SS-31 improves cardiac contractility in models of heart failure, enhances muscle performance in aging or disease paradigms, and supports bioenergetic efficiency in skeletal muscle.[5][6]
  • Neuroprotection & Age-Related Decline – Animal studies suggest SS-31 attenuates neuronal loss, reduces neuroinflammation, and improves cognitive function in models of Alzheimer’s disease, Parkinson’s disease, and age-related mitochondrial dysfunction.[7][8]

Product Specifications

CAS Number 736992-21-5
Molecular Formula C32H49N9O5
Molar Mass 639.79 g/mol
Sequence D-Arg-Dmt-Lys-Phe-NH2
Synonyms Elamipretide, Bendavia, Szeto-Schiller peptide 31, SS-31 peptide
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Szeto HH. Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J. 2006. PubMed
  2. 2. Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent for ischemia-reperfusion injury and heart failure. Br J Pharmacol. 2014. PubMed
  3. 3. Cho DH, et al. SS-31 prevents mitochondrial fragmentation and protects against ischemia/reperfusion injury. J Am Heart Assoc. 2017. PubMed
  4. 4. Manczak M, et al. Mitochondria-targeted antioxidant SS-31 improves mitochondrial function in Alzheimer’s disease mouse model. J Alzheimers Dis. 2016. PubMed
  5. 5. Dai DF, et al. Mitochondrial-targeted antioxidant therapy attenuates heart failure progression in rats. J Am Coll Cardiol. 2014. PubMed
  6. 6. Birk AV, et al. The mitochondrial-targeted compound SS-31 reenergizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013. PubMed
  7. 7. Reddy PH, et al. Mitochondria-targeted peptides protect against amyloid-β toxicity in Alzheimer’s disease models. Biochim Biophys Acta. 2018. PubMed
  8. 8. Yin X, et al. SS-31 improves mitochondrial dynamics and protects against Parkinson’s disease models. Front Pharmacol. 2021. PubMed
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