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DSIP 5MG

DSIP 5MG

$36.00

DSIP DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from cerebral venous blood of rabbits during sleep induction. Preclinical studies in animal models indicate that DSIP may modulate sleep patterns, exert stress-protective effects, and influence neuroendocrine regulation. Research has explored its potential to promote delta-wave sleep and normalize disturbed sleep architecture in various experimental…

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DSIP

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from cerebral venous blood of rabbits during sleep induction. Preclinical studies in animal models indicate that DSIP may modulate sleep patterns, exert stress-protective effects, and influence neuroendocrine regulation. Research has explored its potential to promote delta-wave sleep and normalize disturbed sleep architecture in various experimental paradigms.[1][2]

Key Research Areas

  • Sleep Regulation & Delta-Wave Promotion – In rabbit and rat models, DSIP administration has been shown to increase delta (slow-wave) sleep duration, reduce sleep latency, and normalize sleep-wake cycles in stress-induced or pharmacologically disrupted sleep patterns.[3][4]
  • Stress Protection & Adaptation – Preclinical investigations demonstrate DSIP’s ability to attenuate stress responses, protect against metabolic disturbances under chronic stress, and modulate HPA axis activity in animal models of immobilization or cold stress.[5][6]
  • Neuroendocrine & Pain Modulation Pathways – Studies suggest DSIP influences opioid systems, reduces nociceptive responses in pain models, and affects release of hormones such as LH and GH in certain experimental conditions.[7][8]

Product Specifications

CAS Number 62568-57-4
Molecular Formula C35H48N10O15
Molar Mass 848.82 g/mol
Sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Synonyms Delta Sleep-Inducing Peptide, DSIP nonapeptide
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Schneider-Helmert D, et al. Delta sleep-inducing peptide (DSIP): a review. Neuropsychobiology. 1984. PubMed
  2. 2. Kovalzon VM, et al. Delta sleep-inducing peptide (DSIP): twenty years of research. Neurosci Behav Physiol. 2001. PubMed
  3. 3. Graf M, et al. Delta sleep-inducing peptide promotes slow-wave sleep in rabbits. Neurosci Lett. 1984. PubMed
  4. 4. Monti JM, et al. Delta sleep-inducing peptide (DSIP) and its effects on sleep in rats. Pharmacol Biochem Behav. 1987. PubMed
  5. 5. Khvatova EM, et al. Delta sleep-inducing peptide (DSIP) and its analogs as potential therapeutic agents. Peptides. 2003. PubMed
  6. 6. Schneider-Helmert D. DSIP: delta sleep-inducing peptide and its analogs. Trends Pharmacol Sci. 1985. PubMed
  7. 7. Graf M, et al. DSIP reduces nociceptive responses in mice. Neuropeptides. 1985. PubMed
  8. 8. Kovalzon VM, et al. DSIP: effects on endocrine functions in rats. Neuroendocrinol Lett. 1998. (Endocrine modulation data)
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