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MT-2 10MG

MT-2 10MG

$40.00

MT-2 MT-2 (Melanotan-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) with enhanced stability and potency at melanocortin receptors (primarily MC1R and MC4R). Preclinical studies in cell cultures and animal models indicate that MT-2 potently stimulates melanogenesis, provides photoprotection, and modulates central nervous system pathways related to appetite, sexual behavior, and inflammation.[1][2] Key…

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MT-2

MT-2 (Melanotan-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) with enhanced stability and potency at melanocortin receptors (primarily MC1R and MC4R). Preclinical studies in cell cultures and animal models indicate that MT-2 potently stimulates melanogenesis, provides photoprotection, and modulates central nervous system pathways related to appetite, sexual behavior, and inflammation.[1][2]

Key Research Areas

  • Melanogenesis & Photoprotection – In melanocyte cultures and rodent models, MT-2 has been shown to strongly induce eumelanin production, darken skin pigmentation, and offer protection against UV-induced DNA damage and sunburn.[3][4]
  • Anti-Inflammatory & Immunomodulatory Effects – Preclinical investigations demonstrate MT-2 reduces pro-inflammatory cytokine release, attenuates inflammatory responses in models of dermatitis, arthritis, and systemic inflammation via melanocortin receptor activation.[5][6]
  • Central Nervous System & Behavioral Pathways – Animal studies indicate MT-2 influences MC4R-mediated pathways, affecting appetite suppression, sexual arousal/behavior, and potential neuroprotective effects in models of brain injury and neurodegeneration.[7][8]

Product Specifications

CAS Number 121062-08-6
Molecular Formula C50H69N15O9
Molar Mass 1024.18 g/mol
Sequence Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (cyclized via Asp-Lys side-chain amide bond)
Synonyms Melanotan-II, MT-II, [Nle4,D-Phe7]-α-MSH cyclic analog
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Hadley ME, et al. Melanocortin peptides: structure, function, and pharmacology. Ann N Y Acad Sci. 1996. PubMed
  2. 2. Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase I clinical study. Life Sci. 2000. PubMed
  3. 3. Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: binding and bioactivity. Proc Natl Acad Sci U S A. 1980. PubMed
  4. 4. Levine N, et al. Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. Arch Dermatol. 1991. PubMed
  5. 5. Brzoska T, et al. α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo. Endocr Rev. 2008. PubMed
  6. 6. Catania A, et al. The melanocortin 1 receptor and the UV response of human melanocytes – a shift in paradigm. J Invest Dermatol. 2003. PubMed
  7. 7. Wikberg JE. Melanocortin receptors: new opportunities for drug discovery. Eur J Pharmacol. 2001. PubMed
  8. 8. Hadley ME, et al. Discovery and development of the melanocortin agonists. Ann N Y Acad Sci. 2003. PubMed
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