Premier Research

VIP 10MG

VIP 10MG

$85.00

VIP VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide originally isolated from porcine intestine. Preclinical studies in cell cultures and animal models indicate that VIP acts as a neuromodulator and vasodilator, exerting anti-inflammatory, neuroprotective, and immunomodulatory effects through activation of VPAC1 and VPAC2 receptors.[1][2] Key Research Areas Anti-Inflammatory & Immunomodulatory Effects – In rodent…

9 in stock

Category:
Tags:

VIP

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide originally isolated from porcine intestine. Preclinical studies in cell cultures and animal models indicate that VIP acts as a neuromodulator and vasodilator, exerting anti-inflammatory, neuroprotective, and immunomodulatory effects through activation of VPAC1 and VPAC2 receptors.[1][2]

Key Research Areas

  • Anti-Inflammatory & Immunomodulatory Effects – In rodent models of inflammation (e.g., colitis, arthritis, sepsis), VIP has been shown to reduce pro-inflammatory cytokine production, inhibit NF-κB activation, and promote regulatory T-cell function.[3][4]
  • Neuroprotection & Brain Function – Preclinical investigations demonstrate VIP protects neurons from excitotoxicity and oxidative stress, enhances neurogenesis, and improves cognitive outcomes in models of brain ischemia, Parkinson’s, and Alzheimer’s disease.[5][6]
  • Vasodilation & Gastrointestinal Regulation – Animal studies suggest VIP relaxes smooth muscle, increases blood flow, and supports intestinal motility and secretion in models of gut inflammation and vascular dysfunction.[7][8]

Product Specifications

CAS Number 37221-79-7
Molecular Formula C147H238N44O48S
Molar Mass 3325.84 g/mol
Sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Synonyms Vasoactive Intestinal Peptide, VIP 28
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Said SI, et al. Vasoactive intestinal peptide: a new neurotransmitter. Ann N Y Acad Sci. 1988. PubMed
  2. 2. Delgado M, et al. Vasoactive intestinal peptide: a regulator of immunity. Ann N Y Acad Sci. 2006. PubMed
  3. 3. Delgado M, et al. Vasoactive intestinal peptide inhibits IL-8 production in human monocytes by down-regulating NF-kappaB. J Immunol. 1999. PubMed
  4. 4. Abad C, et al. Vasoactive intestinal peptide protects against experimental murine colitis. Br J Pharmacol. 2003. PubMed
  5. 5. Delgado M, et al. Neuroprotective effect of vasoactive intestinal peptide in a murine model of Parkinson’s disease. J Neuroimmunol. 2003. PubMed
  6. 6. Gozes I, et al. Vasoactive intestinal peptide (VIP) protects hippocampal neurons from death induced by beta-amyloid. Neuroendocrinology. 1999. PubMed
  7. 7. Delgado M, et al. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNF-alpha production. J Immunol. 1998. PubMed
  8. 8. Gonzalez-Rey E, et al. Vasoactive intestinal peptide and regulatory T-cell induction. Trends Immunol. 2007. PubMed
All products offered by Premier Research are intended for laboratory research use only. These materials are not for human or veterinary consumption, medical use, diagnostic procedures, or therapeutic applications. Statements on this website are for informational and educational purposes only and have not been evaluated by the U.S. Food and Drug Administration (FDA). By accessing this site, you confirm that you are a qualified researcher or institution representative and agree to use all materials in accordance with applicable laws, regulations, and safety guidelines.

Related products