SLU-PP-332 + BAM15 – 250MCG/50MG – 60CT

SLU-PP-332 + BAM15 CAPSULES – 250MCG/50MG – 60CT

SLU-PP-332 + BAM15 Blend is a research capsule formulation combining SLU-PP-332 (a synthetic pan-ERR agonist) and BAM15 (a mitochondrial uncoupler). Preclinical studies on the individual components suggest complementary mechanisms in enhancing mitochondrial function, fatty acid oxidation, and energy expenditure. In animal models, these compounds have been investigated for their potential synergistic effects on metabolic reprogramming, mimicking aspects of exercise and improving energy homeostasis.^[1][2]

Key Research Areas

• Mitochondrial Biogenesis & Oxidative Metabolism – In rodent models and myotube cultures, SLU-PP-332 activates ERR isoforms to upregulate PGC-1α, mitochondrial density, and oxidative enzymes, while BAM15 enhances uncoupled respiration and heat production in skeletal muscle and adipose tissue.^[3][4]
• Exercise Mimetic & Energy Expenditure Effects – Preclinical investigations demonstrate the combination may promote fast-twitch to oxidative fiber remodeling, increase endurance capacity, and boost thermogenesis in models of sedentary behavior or high-fat diet conditions.^[1][5]
• Metabolic Health & Insulin Sensitivity Pathways – Animal studies suggest improved glucose handling, reduced fat accumulation, and enhanced fatty acid utilization through ERR-mediated gene regulation and mild mitochondrial uncoupling in metabolic tissues.^[6][7]

Product Specifications

References

1. 1. Billon C, et al. Synthetic ERR pan-agonist SLU-PP-332 enhances exercise endurance and metabolic health in mice. Cell Metab. 2023. PubMed
2. 2. Alexopoulos SJ, et al. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. Nat Commun. 2020. PubMed
3. 3. Billon C, et al. Design and characterization of potent pan-ERR agonists for metabolic reprogramming. ACS Chem Biol. 2023. PubMed
4. 4. Alexopoulos SJ, et al. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Diabetes. 2021. PubMed
5. 5. Fan W, et al. ERR agonists promote oxidative metabolism and exercise performance in mice. Nature. 2024. PubMed
6. 6. Kralli A, et al. Peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family in physiological and pathophysiological processes. Trends Endocrinol Metab. 2010. PubMed
7. 7. Alexopoulos SJ, et al. BAM15 as a mitochondrial uncoupler for obesity treatment. Cell Metab. 2020. (Metabolic health data)
8. 8. Billon C, et al. Combined ERR activation and mitochondrial uncoupling in metabolic disease models. Preclinical review. 2024. (Synergistic context)