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SNAP-8 10MG

SNAP-8 10MG

$40.00

SNAP-8 SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide analog of SNAP-25 protein fragment, designed as a competitive inhibitor of SNARE complex formation. Preclinical studies in cell cultures and ex vivo skin models indicate that SNAP-8 reduces neurotransmitter release from motor neurons, leading to decreased muscle contraction and relaxation of facial expression lines.[1][2] Key Research Areas…

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SNAP-8

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide analog of SNAP-25 protein fragment, designed as a competitive inhibitor of SNARE complex formation. Preclinical studies in cell cultures and ex vivo skin models indicate that SNAP-8 reduces neurotransmitter release from motor neurons, leading to decreased muscle contraction and relaxation of facial expression lines.[1][2]

Key Research Areas

  • Neuromuscular Signaling Inhibition – In vitro neuronal cell models demonstrate SNAP-8 interferes with SNARE complex assembly (SNAP-25, VAMP, syntaxin), reducing acetylcholine release at neuromuscular junctions and attenuating muscle fiber contraction.[3][4]
  • Skin Wrinkle Reduction Models – Ex vivo human skin explants and 3D reconstructed epidermis studies show SNAP-8 decreases dynamic wrinkle depth by modulating facial muscle activity and improving skin surface smoothness parameters.[5][6]
  • Anti-Wrinkle & Expression Line Pathways – Preclinical investigations suggest SNAP-8 provides a reversible, non-toxic alternative to neurotoxin mechanisms, supporting research into cosmetic peptide modulation of facial muscle tone without permanent effects.[7][8]

Product Specifications

CAS Number 868844-74-0
Molecular Formula C41H70N16O16S
Molar Mass 1079.25 g/mol
Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Arg-Gln-NH2
Synonyms Acetyl Octapeptide-3, SNAP-8 Acetate, Anti-wrinkle peptide SNAP-8
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity in vivo. Int J Cosmet Sci. 2002. PubMed
  2. 2. Wang Y, et al. Acetyl hexapeptide-3 and acetyl octapeptide-3: Structure-activity relationship in wrinkle reduction. J Cosmet Dermatol. 2013. PubMed
  3. 3. Ruiz MA, et al. SNAP-8 inhibits SNARE complex formation and neurotransmitter release in vitro. Peptides. 2010. (SNARE inhibition data)
  4. 4. Dragomirescu AO, et al. The influence of acetyl octapeptide-3 on muscle contraction in ex vivo models. Cosmetics. 2019. (Ex vivo muscle data)
  5. 5. Schagen SK. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017. PubMed
  6. 6. Lupo MP, et al. Cosmeceutical peptides. Dermatol Surg. 2005. PubMed
  7. 7. Gorouhi F, et al. Role of topical peptides in prevention and treatment of skin aging. Clin Interv Aging. 2010. PubMed
  8. 8. Wang Y, et al. Comparative anti-wrinkle efficacy of SNAP-8 and related peptides. J Cosmet Sci. 2015. (Comparative data)
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