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TESAMORELIN 10MG
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TESAMORELIN 10MG

$80.00

Tesamorelin Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 44 amino acids with a C-terminal modification for stability. Preclinical studies in cell cultures and animal models indicate that Tesamorelin stimulates pituitary somatotrophs to release endogenous growth hormone (GH) in a pulsatile manner, leading to elevated circulating GH and IGF-1 levels without…

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Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 44 amino acids with a C-terminal modification for stability. Preclinical studies in cell cultures and animal models indicate that Tesamorelin stimulates pituitary somatotrophs to release endogenous growth hormone (GH) in a pulsatile manner, leading to elevated circulating GH and IGF-1 levels without significant disruption of the natural feedback axis.[1][2]

Key Research Areas

  • Growth Hormone Secretion & Pulsatile Dynamics – In rodent and primate models, Tesamorelin has been shown to induce physiological GH pulses, mimicking natural episodic secretion and supporting research into the GH axis in metabolic and aging paradigms.[3][4]
  • Metabolic & Body Composition Effects – Preclinical investigations demonstrate enhanced lipolysis, reduced visceral fat accumulation, and improved lipid profiles in animal models of metabolic dysfunction and growth hormone deficiency.[5][6]
  • Tissue Maintenance & Anabolic Pathways – Animal studies suggest Tesamorelin supports protein synthesis, nitrogen retention, and connective tissue integrity through elevated GH/IGF-1 signaling in models of aging or injury.[7][8]

Product Specifications

CAS Number 218949-78-5
Molecular Formula C221H366N72O67S
Molar Mass 5135.89 g/mol
Sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Synonyms TH-9507, GHRH (1-44) NH2, Tesamorelin Acetate
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Merriam GR, et al. Growth hormone-releasing hormone: a review of its use in adults with growth hormone deficiency. Drugs. 2003. PubMed
  2. 2. Falutz J, et al. Metabolic effects of a growth hormone-releasing hormone analog in HIV-infected men with excess visceral fat. J Clin Endocrinol Metab. 2007. PubMed
  3. 3. Koutkia P, et al. Growth hormone-releasing hormone (GHRH) in HIV-associated lipodystrophy. J Clin Endocrinol Metab. 2004. PubMed
  4. 4. Stanley TL, et al. Effects of tesamorelin on fat metabolism in HIV-infected patients with abdominal fat accumulation. J Clin Endocrinol Metab. 2012. PubMed
  5. 5. Falutz J, et al. Effects of tesamorelin, a growth hormone-releasing factor, in patients with HIV lipodystrophy. N Engl J Med. 2010. PubMed
  6. 6. Veldhuis JD, et al. Growth hormone secretagogues: history, mechanism of action, and clinical development. Growth Horm IGF Res. 2010. PubMed
  7. 7. Sigalos JT, et al. The safety and efficacy of growth hormone secretagogues. Sex Med Rev. 2018. PubMed
  8. 8. Stanley TL, et al. Tesamorelin in HIV-associated lipodystrophy: effects on body composition and metabolic parameters. J Clin Endocrinol Metab. 2011. PubMed
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