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KPV 10MG

KPV 10MG

$70.00

KPV KPV (Lys-Pro-Val) is a tripeptide derived from alpha-melanocyte-stimulating hormone (α-MSH). Preclinical studies in cell cultures and animal models indicate that KPV exhibits potent anti-inflammatory and antimicrobial properties, reducing pro-inflammatory cytokine production and supporting mucosal integrity in various inflammatory paradigms.[1][2] Key Research Areas Anti-Inflammatory Effects in Gut Models – In rodent models of inflammatory bowel…

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KPV

KPV (Lys-Pro-Val) is a tripeptide derived from alpha-melanocyte-stimulating hormone (α-MSH). Preclinical studies in cell cultures and animal models indicate that KPV exhibits potent anti-inflammatory and antimicrobial properties, reducing pro-inflammatory cytokine production and supporting mucosal integrity in various inflammatory paradigms.[1][2]

Key Research Areas

  • Anti-Inflammatory Effects in Gut Models – In rodent models of inflammatory bowel disease (e.g., DSS-induced colitis), KPV has been shown to decrease colonic inflammation, reduce TNF-α and IL-1β levels, and improve mucosal histology.[3][4]
  • Immune Modulation & Cytokine Regulation – Preclinical investigations demonstrate KPV inhibits NF-κB activation in macrophages and epithelial cells, suppresses excessive cytokine release, and modulates innate immune responses in models of dermatitis and systemic inflammation.[5][6]
  • Antimicrobial & Barrier Protection Pathways – Studies in microbial challenge models suggest KPV exhibits direct antimicrobial activity against certain pathogens while supporting epithelial barrier function and wound healing in skin and mucosal tissues.[7][8]

Product Specifications

CAS Number 67727-23-5
Molecular Formula C16H30N4O4
Molar Mass 342.43 g/mol
Sequence Lys-Pro-Val
Synonyms Lysine-Proline-Valine, α-MSH(11-13), KPV tripeptide
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Rajora N, et al. α-MSH modulates local and circulating tumor necrosis factor-α in experimental inflammatory bowel disease. J Immunol. 1997. PubMed
  2. 2. Brzoska T, et al. α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008. PubMed
  3. 3. Kannengiesser K, et al. Melanocortin-1 receptor agonist protects against experimental colitis in mice. Peptides. 2008. PubMed
  4. 4. Catania A, et al. The neuropeptide α-MSH in the anti-inflammatory network. Ann N Y Acad Sci. 1998. PubMed
  5. 5. Mastrofrancesco A, et al. KPV tripeptide reduces pro-inflammatory cytokine production in human keratinocytes. J Invest Dermatol. 2010. (Anti-inflammatory data)
  6. 6. Cutuli M, et al. α-MSH and its tripeptide fragment KPV: novel anti-inflammatory agents in experimental models. Peptides. 2000. PubMed
  7. 7. Elliott RJ, et al. Antimicrobial activity of the α-MSH-derived tripeptide KPV in vitro. Antimicrob Agents Chemother. 2004. (Antimicrobial data)
  8. 8. Catania A. The protective effect of melanocortin peptides in inflammatory disorders. Trends Immunol. 2007. PubMed
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