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MT-1 10MG

MT-1 10MG

$40.00

MT-1 MT-1 (Melanotan-1) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (α-MSH) with an N-terminal acetyl group and C-terminal amidation for enhanced stability. Preclinical studies in cell cultures and animal models indicate that MT-1 acts as a potent melanocortin receptor agonist (primarily MC1R), promoting melanogenesis, photoprotection, and modulating inflammatory responses in skin and other tissues.[1][2]…

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MT-1

MT-1 (Melanotan-1) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (α-MSH) with an N-terminal acetyl group and C-terminal amidation for enhanced stability. Preclinical studies in cell cultures and animal models indicate that MT-1 acts as a potent melanocortin receptor agonist (primarily MC1R), promoting melanogenesis, photoprotection, and modulating inflammatory responses in skin and other tissues.[1][2]

Key Research Areas

  • Melanogenesis & Photoprotection – In melanocyte cultures and rodent models, MT-1 has been shown to increase melanin production (eumelanin), enhance skin pigmentation, and provide photoprotective effects against UV-induced damage.[3][4]
  • Anti-Inflammatory & Immunomodulatory Effects – Preclinical investigations demonstrate MT-1 reduces pro-inflammatory cytokine release, modulates immune cell activity, and attenuates inflammatory responses in models of dermatitis and systemic inflammation.[5][6]
  • Neuroprotective & Behavioral Pathways – Animal studies suggest MT-1 influences melanocortin receptor signaling in the central nervous system, potentially affecting appetite regulation, sexual behavior, and neuroprotection in models of brain injury.[7][8]

Product Specifications

CAS Number 75921-69-6
Molecular Formula C78H111N21O19
Molar Mass 1646.85 g/mol
Sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Synonyms Melanotan-1, Afamelanotide (clinical name for related form), [Nle4,D-Phe7]-α-MSH
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Hadley ME, et al. Melanocortin peptides: structure, function, and pharmacology. Ann N Y Acad Sci. 1996. PubMed
  2. 2. Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase I clinical study. Life Sci. 2000. PubMed
  3. 3. Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: binding and bioactivity. Proc Natl Acad Sci U S A. 1980. PubMed
  4. 4. Levine N, et al. Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. Arch Dermatol. 1991. PubMed
  5. 5. Brzoska T, et al. α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo. Endocr Rev. 2008. PubMed
  6. 6. Catania A, et al. The melanocortin 1 receptor and the UV response of human melanocytes – a shift in paradigm. J Invest Dermatol. 2003. PubMed
  7. 7. Wikberg JE. Melanocortin receptors: new opportunities for drug discovery. Eur J Pharmacol. 2001. PubMed
  8. 8. Hadley ME, et al. Discovery and development of the melanocortin agonists. Ann N Y Acad Sci. 2003. PubMed
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