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SEMAX 10MG

SEMAX 10MG

$45.00

Semax Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment 4-10 (Met-Glu-His-Phe-Pro-Gly-Pro) with a C-terminal Pro-Gly-Pro extension. Preclinical studies in cell cultures and animal models indicate that Semax exhibits neuroprotective, nootropic, and neurotrophic effects, enhancing BDNF expression, modulating dopaminergic and serotonergic systems, and supporting cognitive function under stress.[1][2] Key Research Areas Neuroprotection &…

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Semax

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment 4-10 (Met-Glu-His-Phe-Pro-Gly-Pro) with a C-terminal Pro-Gly-Pro extension. Preclinical studies in cell cultures and animal models indicate that Semax exhibits neuroprotective, nootropic, and neurotrophic effects, enhancing BDNF expression, modulating dopaminergic and serotonergic systems, and supporting cognitive function under stress.[1][2]

Key Research Areas

  • Neuroprotection & Brain Injury Recovery – In rodent models of cerebral ischemia, traumatic brain injury, and oxidative stress, Semax has been shown to reduce neuronal damage, decrease infarct size, improve neurological scores, and enhance survival of brain cells.[3][4]
  • Cognitive Enhancement & Memory Processes – Preclinical investigations demonstrate Semax improves learning, memory consolidation, and attention in models of impaired cognition (e.g., induced by scopolamine, stress, or aging), with increased BDNF and NGF expression in hippocampal and cortical regions.[5][6]
  • Stress Adaptation & Neurotransmitter Modulation – Animal studies suggest Semax normalizes stress-induced changes in serotonin, dopamine, and enkephalin levels, reduces anxiety-like behaviors, and supports adaptive responses in chronic stress paradigms.[7][8]

Product Specifications

CAS Number 80714-61-0
Molecular Formula C37H51N9O10S
Molar Mass 813.93 g/mol
Sequence Met-Glu-His-Phe-Pro-Gly-Pro
Synonyms Semax, Semax heptapeptide, ACTH(4-10) analog
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Ashmarin IP, et al. Design and study of a new class of peptide bioregulators. Bull Exp Biol Med. 2002. PubMed
  2. 2. Kaplan AY, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurosci Behav Physiol. 1996. PubMed
  3. 3. Gusev EI, et al. Neuroprotective effect of Semax in experimental models of cerebral ischemia. Bull Exp Biol Med. 2000. PubMed
  4. 4. Miasoedov NF, et al. Semax in the therapy of patients with acute ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 1999. (Preclinical context)
  5. 5. Dolotov OV, et al. Semax, a synthetic ACTH(4-10) analogue, enhances BDNF expression in rat hippocampus. Neurosci Lett. 2006. PubMed
  6. 6. Levitskaya NG, et al. Semax improves memory consolidation in rats with scopolamine-induced amnesia. Bull Exp Biol Med. 2008. PubMed
  7. 7. Medvedev VE, et al. Selank and Semax in experimental models of stress and anxiety. Zh Nevrol Psikhiatr Im S S Korsakova. 2007. (Related stress data)
  8. 8. Eremin KO, et al. Semax modulates enkephalin and serotonin systems in rat brain under stress. Bull Exp Biol Med. 2005. PubMed
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