CEREBROLYSIN 60MG

Cerebrolysin

Cerebrolysin is a low-molecular-weight neuropeptides and free amino acids derived from the enzymatic hydrolysis of porcine brain tissue. In research contexts, it is supplied as a lyophilized powder for reconstitution. Preclinical studies in various animal models indicate that Cerebrolysin exhibits neuroprotective effects, including reduction of neuronal apoptosis, promotion of neurotrophic factor activity, and support for neuroplasticity and functional recovery in models of ischemic stroke, traumatic brain injury, and other neurological insults.^[1][2]

Key Research Areas

• Neuroprotection in Ischemic & Traumatic Injury – In rat models of middle cerebral artery occlusion and traumatic brain injury, Cerebrolysin has been shown to reduce infarct volume, decrease edema, preserve neuronal integrity, and improve neurological functional outcomes.^[3][4]
• Promotion of Neuroplasticity & Regeneration – Preclinical investigations demonstrate enhancement of neurogenesis, synaptic plasticity, and neurotrophic factor signaling (e.g., BDNF-like effects), supporting neuronal survival and recovery in models of excitotoxicity and chronic neurodegeneration.^[5][6]
• Anti-Inflammatory & Antioxidant Pathways – Animal studies suggest modulation of inflammatory responses, reduction of microglial activation, and activation of antioxidant pathways (e.g., Keap1/Nrf2) in models of forebrain ischemia-reperfusion and autoimmune encephalitis.^[7][8]

Product Specifications

References

1. 1. Masliah E, et al. The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders. Drugs Today. 2012. PubMed
2. 2. Sharma HS, et al. Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat. Ann N Y Acad Sci. 2010. PubMed
3. 3. Zhang L, et al. Cerebrolysin dose-dependently improves neurological outcome in rats after acute stroke: A prospective, randomized, blinded, and placebo-controlled study. Int J Stroke. 2016. PubMed
4. 4. Marghani BH, et al. The Effect of Cerebrolysin in an Animal Model of Forebrain Ischemic-Reperfusion Injury: New Insights into the Activation of the Keap1/Nrf2/Antioxidant Signaling Pathway. Int J Mol Sci. 2023. PubMed
5. 5. Rockenstein E, et al. Neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer’s disease are associated with improved behavioral performance. J Neural Transm. 2003. PubMed
6. 6. Chen CC, et al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome in rats. Stroke. 2007. PubMed
7. 7. Morega S, et al. Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage. Brain Sci. 2021. PubMed
8. 8. Khasanova DR, et al. Cerebrolysin increases motor recovery and decreases inflammation in a mouse model of autoimmune encephalitis. Brain Behav. 2018. PubMed