AHK-CU 50MG

AHK-Cu

AHK-Cu (L-alanyl-L-histidyl-L-lysine copper complex) is a synthetic copper-bound tripeptide analog of glycyl-L-histidyl-L-lysine (GHK-Cu), designed to enhance stability and activity in certain models. Preclinical studies indicate that AHK-Cu promotes dermal papilla cell proliferation, reduces apoptosis, and stimulates hair follicle elongation ex vivo, while also supporting collagen synthesis and extracellular matrix remodeling in fibroblast cultures.^[1][2]

Key Research Areas

• Hair Follicle Growth & Regeneration – Ex vivo human hair follicle models and cultured dermal papilla cells show AHK-Cu stimulates elongation, enhances proliferation, and inhibits apoptosis via modulation of Bcl-2/Bax ratios and caspase pathways.^[1]
• Wound Healing & Tissue Remodeling – In vitro fibroblast studies demonstrate AHK-Cu increases collagen and glycosaminoglycan synthesis, upregulates matrix metalloproteinase expression, and promotes balanced extracellular matrix turnover.^[2][3]
• Antioxidant & Anti-Inflammatory Pathways – Preclinical models suggest copper-tri peptide complexes like AHK-Cu elevate antioxidant enzyme levels and modulate inflammatory responses during tissue repair processes.^[4][5]

Product Specifications

References

1. 1. Pyo HK, et al. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007. PubMed
2. 2. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988. PubMed
3. 3. Siméon A, et al. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000. PubMed
4. 4. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. PubMed
5. 5. Wegrowski Y, et al. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sci. 1992. PubMed