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AOD-9604 5MG

AOD-9604 5MG

$40.00

AOD-9604 AOD-9604 is a synthetic peptide analog of the C-terminal fragment (amino acids 177-191) of human growth hormone, modified with an N-terminal tyrosine and a disulfide bridge for stability. Preclinical research indicates that AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without binding to the growth hormone receptor or elevating IGF-1 levels. Studies in…

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AOD-9604

AOD-9604 is a synthetic peptide analog of the C-terminal fragment (amino acids 177-191) of human growth hormone, modified with an N-terminal tyrosine and a disulfide bridge for stability. Preclinical research indicates that AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without binding to the growth hormone receptor or elevating IGF-1 levels. Studies in obese animal models have demonstrated reduced body weight gain and increased fat oxidation, while preserving insulin sensitivity.[1][2]

Key Research Areas

  • Lipid Metabolism & Adiposity – In obese mouse and rat models, chronic administration of AOD-9604 has been shown to reduce body weight gain, enhance fat oxidation, and increase lipolytic activity in adipose tissue via upregulation of β3-adrenergic receptor expression.[1][3]
  • Cartilage Regeneration – Intra-articular injections in a collagenase-induced osteoarthritis rabbit model suggest enhanced cartilage repair, with greater effects observed when combined with hyaluronic acid.[4]
  • Metabolic Pathways – Unlike intact hGH, AOD-9604 does not appear to induce hyperglycemia or impair insulin sensitivity in preclinical models, while promoting lipolysis and inhibiting acetyl-CoA carboxylase activity.[2][5]

Product Specifications

CAS Number 221231-10-3
Molecular Formula C78H123N23O23S2
Molar Mass 1815.12 g/mol
Sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge: Cys7-Cys15)
Synonyms AOD9604, Tyr-hGH 177-191
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term)
Solubility Water or acetic acid; bacteriostatic water for reconstitution

References

  1. 1. Heffernan M, et al. The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and β3-AR Knock-Out Mice. Endocrinology. 2001. PubMed
  2. 2. Ng FM, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000. PubMed
  3. 3. Heffernan MA, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001. PubMed
  4. 4. Son JH, et al. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015. PubMed
  5. 5. Ng FM, et al. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000. PubMed
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