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EPITALON 10MG

EPITALON 10MG

$36.00

Epitalon Epitalon (also known as Epithalon or Epithalamin fragment) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled after a pineal gland-derived peptide. Preclinical studies in animal models and cell cultures indicate that Epitalon may activate telomerase, promote telomere elongation, and exhibit geroprotective effects, including increased lifespan, reduced tumor incidence, and modulation of pineal gland function.[1][2] Key Research…

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Epitalon

Epitalon (also known as Epithalon or Epithalamin fragment) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled after a pineal gland-derived peptide. Preclinical studies in animal models and cell cultures indicate that Epitalon may activate telomerase, promote telomere elongation, and exhibit geroprotective effects, including increased lifespan, reduced tumor incidence, and modulation of pineal gland function.[1][2]

Key Research Areas

  • Telomere Maintenance & Cellular Longevity – In human somatic cell cultures and aging mouse models, Epitalon has been shown to induce telomerase activity, elongate telomeres, reduce chromosomal aberrations, and extend proliferative potential beyond the Hayflick limit.[3][4]
  • Geroprotection & Lifespan Extension – In rodent models (including SHR mice and Drosophila), chronic administration of Epitalon has been associated with increased mean and maximum lifespan, decreased biomarkers of aging, and improved survival without increased tumor development.[5][6]
  • Tumor Suppression & Anticarcinogenic Effects – Preclinical studies in transgenic and inbred mouse strains demonstrate reduced spontaneous mammary tumor development, decreased metastasis incidence, and inhibitory effects on carcinogenesis.[7][8]

Product Specifications

CAS Number 307297-39-8
Molecular Formula C14H22N4O9
Molar Mass 390.35 g/mol
Sequence Ala-Glu-Asp-Gly
Synonyms Epithalon, Epitalone, AEDG tetrapeptide
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003. PubMed
  2. 2. Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003. PubMed
  3. 3. Araj SK, et al. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025. PubMed
  4. 4. Khavinson VK, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. PubMed
  5. 5. Anisimov VN, et al. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002. PubMed
  6. 6. Khavinson VK, et al. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2001. PubMed
  7. 7. Khavinson VK, et al. Epitalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. Bull Exp Biol Med. 2002. (Tumor suppression data)
  8. 8. Anisimov VN, et al. Twenty years of study on effects of pineal peptide preparation: Epithalamin in experimental gerontology and oncology. Ann N Y Acad Sci. 1994. PubMed
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