BPC-157 + TB-500 + GHK-Cu : GLOW

BPC-157 + TB-500 + GHK-Cu blend is a research peptide combination consisting of the synthetic pentadecapeptide BPC-157 (derived from a gastric protective protein), TB-500 (a synthetic fragment of thymosin beta-4), and GHK-Cu (a copper-binding tripeptide). Preclinical studies suggest that BPC-157 promotes angiogenesis and tissue protection, TB-500 facilitates actin regulation and cell migration, and GHK-Cu supports collagen synthesis and extracellular matrix remodeling. These peptides may exhibit complementary actions in models of wound healing, skin regeneration, and tissue repair.^[1]^[2]

Key Research Areas

Wound Healing & Skin Regeneration – In preclinical models, GHK-Cu has been shown to stimulate collagen and elastin production, enhance fibroblast activity, and promote dermal remodeling; BPC-157 accelerates epithelialization and collagen organization in injury models, while TB-500 supports cell migration and reduces excessive fibrosis.^[3]^[4]
Angiogenesis & Vascular Support – BPC-157 upregulates VEGF signaling in ischemic tissues, TB-500 promotes endothelial cell differentiation and vessel formation, and GHK-Cu enhances capillary growth through copper-dependent pathways in various preclinical wound models.^[5]^[6]
Tissue Remodeling & Anti-Inflammatory Pathways – The combination may modulate inflammatory mediators, support balanced extracellular matrix turnover, and promote antioxidant activity via complementary mechanisms in in vitro and animal studies.^[1]^[7]

Product Specifications

CAS Number	BPC-157: 137525-51-0 / TB-500: 77591-33-4 / GHK-Cu: 49557-75-7
Molecular Formula	Blend (BPC-157: C₆₂H₉₈N₁₆O₂₂ / TB-500: C₂₁₂H₃₅₀N₅₆O₇₈S / GHK-Cu: C₁₄H₂₄CuN₆O₄)
Molar Mass	Blend (BPC-157: 1419.56 g/mol / TB-500: 4963.50 g/mol / GHK-Cu: 403.92 g/mol)
Sequence	BPC-157: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val TB-500: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser GHK-Cu: Gly-His-Lys-Cu²⁺
Synonyms	BPC-157/TB-500/GHK-Cu Blend, Regeneration Blend, GLOW Blend
Purity	≥99% (HPLC)
Form	Lyophilized powder
Storage	−20°C (long-term), 2–8°C (reconstituted)
Solubility	Bacteriostatic water or saline for reconstitution

References

1. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. PubMed
2. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011. PubMed
3. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988. PubMed
4. Philp D, et al. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004. PubMed
5. Seiwerth S, et al. BPC 157 and blood vessels. Curr Pharm Des. 2014. PubMed
6. Smart N, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 2007. PubMed
7. Wang X, et al. GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair Regen. 2017. PubMed

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