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MOTS-C 10MG
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MOTS-C 10MG

Original price was: $49.00.Current price is: $39.00.

MOTS-c MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived cyclic peptide encoded within the mitochondrial 12S rRNA gene. Preclinical studies in cell cultures and animal models indicate that MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and promotes mitochondrial biogenesis and energy expenditure through activation of the AMPK pathway.[1][2] Key Research Areas…

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MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived cyclic peptide encoded within the mitochondrial 12S rRNA gene. Preclinical studies in cell cultures and animal models indicate that MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and promotes mitochondrial biogenesis and energy expenditure through activation of the AMPK pathway.[1][2]

Key Research Areas

  • Metabolic Regulation & Insulin Sensitivity – In rodent models of diet-induced obesity and insulin resistance, MOTS-c administration has been shown to improve glucose tolerance, reduce fat accumulation, and enhance insulin signaling in skeletal muscle and liver tissues.[3][4]
  • Mitochondrial Function & Energy Homeostasis – Preclinical investigations demonstrate MOTS-c translocates to the nucleus under metabolic stress, upregulates genes involved in fatty acid oxidation, and supports mitochondrial biogenesis via the Folate-AICAR-AMPK pathway.[1][5]
  • Exercise Mimetic & Anti-Aging Pathways – Animal studies suggest MOTS-c mimics some effects of physical exercise, protects against age-related metabolic decline, and modulates inflammatory responses in models of aging and high-fat diet challenge.[6][7]

Product Specifications

CAS Number 1374396-34-5
Molecular Formula C101H152N28O22S2
Molar Mass 2174.60 g/mol
Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Synonyms Mitochondrial-derived peptide MOTS-c, MOTS-c peptide
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. PubMed
  2. 2. Reynolds JC, et al. MOTS-c is an exercise mimetic peptide that enhances insulin sensitivity and glucose metabolism in skeletal muscle. Cell Rep. 2021. PubMed
  3. 3. Yin X, et al. MOTS-c improves insulin sensitivity in obese mice by regulating lipid metabolism. Biochem Biophys Res Commun. 2018. PubMed
  4. 4. Lu H, et al. MOTS-c regulates muscle and fat metabolism in high-fat diet-induced obese mice. Front Endocrinol. 2020. PubMed
  5. 5. Kim KH, et al. MOTS-c regulates nuclear gene expression and mitochondrial function under metabolic stress. Cell Metab. 2018. PubMed
  6. 6. Reynolds JC, et al. MOTS-c is an aging-related peptide that improves physical performance in aged mice. Cell Rep. 2021. PubMed
  7. 7. Kong Y, et al. MOTS-c peptide protects against high-fat diet-induced obesity and insulin resistance in mice. Front Physiol. 2021. PubMed
  8. 8. Lee C, et al. MOTS-c: A novel mitochondrial-derived regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2020. PubMed
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