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NAD+ 500MG

NAD+ 500MG

$80.00

NAD+ NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells, involved in redox reactions and cellular energy transfer. Preclinical studies in cell cultures and animal models indicate that NAD+ supplementation or precursor administration enhances mitochondrial function, activates sirtuins, supports DNA repair, and promotes cellular resilience under metabolic and oxidative stress.[1][2] Key…

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NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells, involved in redox reactions and cellular energy transfer. Preclinical studies in cell cultures and animal models indicate that NAD+ supplementation or precursor administration enhances mitochondrial function, activates sirtuins, supports DNA repair, and promotes cellular resilience under metabolic and oxidative stress.[1][2]

Key Research Areas

  • Mitochondrial Function & Energy Metabolism – In rodent models of aging and metabolic disorder, NAD+ elevation has been shown to improve mitochondrial biogenesis, increase oxidative phosphorylation efficiency, and enhance ATP production via SIRT1 and PGC-1α pathways.[3][4]
  • Sirtuin Activation & Longevity Pathways – Preclinical investigations demonstrate NAD+ serves as a substrate for sirtuins, promoting deacetylation of key proteins involved in DNA repair, inflammation control, and cellular senescence in models of age-related decline.[5][6]
  • Neuroprotection & Stress Resistance – Animal studies suggest NAD+ supports neuronal survival, reduces oxidative damage, and modulates inflammatory responses in models of neurodegeneration, ischemia, and traumatic injury.[7][8]

Product Specifications

CAS Number 53-84-9 (NAD+ free acid)
Molecular Formula C21H27N7O14P2
Molar Mass 663.43 g/mol
Sequence N/A (dinucleotide coenzyme)
Synonyms Nicotinamide Adenine Dinucleotide, β-NAD+, NAD
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Rajman L, et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018. PubMed
  2. 2. Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021. PubMed
  3. 3. Gomes AP, et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013. PubMed
  4. 4. Zhang H, et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016. PubMed
  5. 5. Imai SI, et al. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014. PubMed
  6. 6. Yoshino J, et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011. PubMed
  7. 7. Wang SN, et al. NAD+ and mitochondrial dysfunction in neurodegeneration. Front Cell Neurosci. 2020. PubMed
  8. 8. Lautrup S, et al. NAD+ in brain aging and neurodegenerative disorders. Cell Metab. 2019. PubMed
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