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PHENIBUT 300MG - 60CT

PHENIBUT 300MG – 60CT

$35.00

PHENIBUT CAPSULES 300MG – 60CT Phenibut is a synthetic derivative of the neurotransmitter GABA (γ-aminobutyric acid) with a phenyl ring addition for enhanced CNS penetration. Preclinical studies in cell cultures and animal models indicate that Phenibut acts primarily as a GABAB receptor agonist, with some GABAA activity, producing anxiolytic, sedative, and nootropic-like effects in various…

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PHENIBUT CAPSULES 300MG – 60CT

Phenibut is a synthetic derivative of the neurotransmitter GABA (γ-aminobutyric acid) with a phenyl ring addition for enhanced CNS penetration. Preclinical studies in cell cultures and animal models indicate that Phenibut acts primarily as a GABAB receptor agonist, with some GABAA activity, producing anxiolytic, sedative, and nootropic-like effects in various behavioral paradigms.[1][2]

Key Research Areas

  • Anxiolytic & Stress-Reduction Effects – In rodent models of anxiety (e.g., elevated plus-maze, conflict tests), Phenibut has been shown to reduce anxiety-like behaviors, increase punished responding, and normalize stress-induced physiological changes without significant motor impairment at low doses.[3][4]
  • GABAB Receptor Modulation & Neurotransmitter Influence – Preclinical investigations demonstrate Phenibut activates GABAB receptors, inhibits adenylate cyclase, reduces excitatory neurotransmission, and modulates dopamine and serotonin release in brain regions involved in mood and cognition.[5][6]
  • Cognitive & Nootropic-Like Properties – Animal studies suggest Phenibut improves memory consolidation, enhances learning in avoidance paradigms, and protects against cognitive deficits in models of brain injury or stress.[7][8]

Product Specifications

Form Capsules (research use only)
CAS Number 1078-21-3
Molecular Formula C10H13NO2
Molar Mass 179.22 g/mol
Synonyms Phenibut, β-Phenyl-GABA, Fenibut
Purity ≥99% (HPLC)
Storage Room temp
Other Details Excipients: Research-grade fillers/capsule material

References

  1. 1. Lapin IP. Phenibut (β-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001. PubMed
  2. 2. Samochai M, et al. Phenibut: a review of its pharmacology, clinical effects, and abuse potential. Pharmacopsychiatry. 2020. PubMed
  3. 3. Lapin IP. Anxiolytic effect of phenibut in conflict situations in rats. Eksp Klin Farmakol. 1995. (Anxiolytic data)
  4. 4. Kaluev AV, et al. Phenibut modulates anxiety-like behavior in rodents. Neurosci Lett. 2008. (Behavioral data)
  5. 5. Möhler H. GABAB receptor pharmacology. Eur J Pharmacol. 2020. PubMed
  6. 6. Bowery NG. GABAB receptor subtypes: pharmacology and clinical implications. Trends Pharmacol Sci. 2006. PubMed
  7. 7. Lapin IP. Phenibut enhances memory in rats with experimental amnesia. Eksp Klin Farmakol. 1999. (Cognitive data)
  8. 8. Vakhitova YV, et al. Phenibut modulates neurotransmitter systems in stress models. Neurochem J. 2007. (Neurotransmitter modulation)
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