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ENCLOMIPHENE 12.5MG - 60CT

ENCLOMIPHENE 12.5MG – 60CT

$89.00

ENCLOMIPHENE CAPSULES 12.5MG – 60CT Enclomiphene is the trans-isomer of clomiphene citrate, a non-steroidal selective estrogen receptor modulator (SERM). Preclinical studies in cell cultures and animal models indicate that Enclomiphene acts as an estrogen receptor antagonist in the hypothalamus and pituitary, leading to increased GnRH, LH, and FSH secretion, thereby stimulating endogenous testosterone production in…

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ENCLOMIPHENE CAPSULES 12.5MG – 60CT

Enclomiphene is the trans-isomer of clomiphene citrate, a non-steroidal selective estrogen receptor modulator (SERM). Preclinical studies in cell cultures and animal models indicate that Enclomiphene acts as an estrogen receptor antagonist in the hypothalamus and pituitary, leading to increased GnRH, LH, and FSH secretion, thereby stimulating endogenous testosterone production in the testes.[1][2]

Key Research Areas

  • Endogenous Testosterone Stimulation – In rodent models of hypogonadism, Enclomiphene has been shown to elevate serum LH and FSH levels, increase testicular testosterone production, and restore spermatogenesis without suppressing the hypothalamic-pituitary-gonadal axis.[3][4]
  • Reproductive & Endocrine Regulation – Preclinical investigations demonstrate Enclomiphene antagonizes estrogen feedback at the pituitary, leading to enhanced gonadotropin release and improved gonadal function in models of age-related or induced hypogonadism.[5][6]
  • Metabolic & Body Composition Effects – Animal studies suggest Enclomiphene supports lean mass maintenance, reduces fat accumulation, and modulates lipid profiles through increased endogenous testosterone signaling in metabolic challenge models.[7][8]

Product Specifications

Form Capsules (research use only)
CAS Number 7599-79-3
Molecular Formula C26H28ClNO
Molar Mass 405.96 g/mol
Synonyms trans-Clomiphene, Enclomiphene citrate (salt form), Androxal (investigational name)
Purity ≥99% (HPLC)
Storage Room temp, protect from light and moisture
Other Details Excipients: Research-grade fillers/capsule material

References

  1. 1. Wiehle RD, et al. Enclomiphene citrate stimulates serum testosterone in men with low testosterone within 14 days. J Mens Health. 2014. PubMed
  2. 2. Katz DJ, et al. Enclomiphene citrate improves hormone levels while preserving sperm production in men with secondary hypogonadism. J Sex Med. 2012. PubMed
  3. 3. Fontenot GK, et al. Enclomiphene citrate increases testosterone in hypogonadal men without suppressing spermatogenesis. J Sex Med. 2011. PubMed
  4. 4. Khera M, et al. Enclomiphene citrate for treatment of secondary male hypogonadism. Expert Opin Investig Drugs. 2016. PubMed
  5. 5. Ramasamy R, et al. Enclomiphene citrate stimulates endogenous testosterone production in men with low testosterone. J Urol. 2015. PubMed
  6. 6. Earl JA, et al. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016. PubMed
  7. 7. Kim ED, et al. Enclomiphene citrate in men with secondary hypogonadism: effects on testosterone and sperm parameters. J Sex Med. 2013. PubMed
  8. 8. Kaminetsky J, et al. Oral enclomiphene citrate raises testosterone and preserves sperm counts in men with secondary hypogonadism: restoration instead of replacement. BJU Int. 2016. PubMed
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