5-AMINO-1MQ 1000MG

5-Amino-1MQ (Liquid)

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Preclinical studies in cell cultures and animal models indicate that 5-Amino-1MQ inhibits NNMT activity, reduces nicotinamide methylation, elevates intracellular NAD⁺ levels, activates sirtuins, and promotes mitochondrial function and metabolic regulation.^[1][2]

Key Research Areas

• Metabolic Regulation & Adiposity – In diet-induced obese mouse models, 5-Amino-1MQ has been shown to reduce body weight gain, decrease fat mass, and enhance fat oxidation through NAD⁺/SIRT1 pathway upregulation without altering food intake.^[1][3]
• Muscle Function & Regeneration – Preclinical studies in aged mouse models demonstrate improved muscle stem cell proliferation, enhanced regenerative capacity after injury, and better functional recovery via NNMT inhibition.^[4]
• Mitochondrial & Longevity Pathways – In vitro and animal research suggests 5-Amino-1MQ elevates NAD⁺, activates sirtuins, improves mitochondrial biogenesis, and supports resistance to age-related metabolic decline.^[2][5]

Product Specifications

References

1. 1. Neelakantan H, et al. Selective NNMT inhibition modulates body composition. Cell Metab. 2019. PubMed
2. 2. Neelakantan H, et al. NNMT inhibition promotes metabolic health and healthspan in mice. Nat Commun. 2021. PubMed
3. 3. Bramblett JW, et al. Small-molecule NNMT inhibitor reduces body weight and fat mass in obese mice. J Pharmacol Exp Ther. 2022. PubMed
4. 4. Wang Y, et al. NNMT inhibition rescues muscle stem cell senescence and improves regenerative capacity in aged mice. Aging Cell. 2023. PubMed
5. 5. Rajman L, et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018. PubMed