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PR-TAD 10MG - 60CT

PR-TAD 10MG – 60CT

$50.00

PR-TAD CAPSULES 10MG – 60CT PR-Tad (Tadalafil) is a synthetic small-molecule phosphodiesterase type 5 (PDE5) inhibitor. Preclinical studies in cell cultures and animal models indicate that Tadalafil selectively inhibits PDE5, leading to increased cyclic GMP (cGMP) levels, smooth muscle relaxation, and enhanced vasodilation in vascular tissues.[1][2] Key Research Areas Vasodilation & Vascular Function – In…

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PR-TAD CAPSULES 10MG – 60CT

PR-Tad (Tadalafil) is a synthetic small-molecule phosphodiesterase type 5 (PDE5) inhibitor. Preclinical studies in cell cultures and animal models indicate that Tadalafil selectively inhibits PDE5, leading to increased cyclic GMP (cGMP) levels, smooth muscle relaxation, and enhanced vasodilation in vascular tissues.[1][2]

Key Research Areas

  • Vasodilation & Vascular Function – In rodent models of vascular dysfunction and pulmonary hypertension, Tadalafil has been shown to relax vascular smooth muscle, improve endothelial function, and enhance blood flow through cGMP-mediated pathways.[3][4]
  • Pulmonary & Cardiovascular Protection – Preclinical investigations demonstrate Tadalafil reduces pulmonary arterial pressure, attenuates right ventricular hypertrophy, and protects against hypoxia-induced vascular remodeling in models of pulmonary arterial hypertension.[5][6]
  • Tissue Perfusion & Anti-Platelet Effects – Animal studies suggest Tadalafil improves tissue perfusion, inhibits platelet aggregation, and supports endothelial integrity in models of ischemia-reperfusion and thrombosis.[7][8]

Product Specifications

Form Oral capsules (research use only)
CAS Number 171596-29-5
Molecular Formula C22H19N3O4
Molar Mass 389.40 g/mol
Synonyms Tadalafil, Tad
Purity ≥99% (HPLC)
Storage Room temp, protect from light and moisture
Other Details Excipients: Research-grade fillers/capsule material

References

  1. 1. Francis SH, et al. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010. PubMed
  2. 2. Corbin JD, et al. The molecular mechanisms of cGMP signaling in vascular smooth muscle. Trends Pharmacol Sci. 2002. PubMed
  3. 3. Galiè N, et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation. 2009. (Preclinical context)
  4. 4. Porst H, et al. Tadalafil once daily in the treatment of erectile dysfunction: efficacy and safety. Eur Urol. 2006. (Vascular data)
  5. 5. McLaughlin VV, et al. Pulmonary arterial hypertension. Circulation. 2009. PubMed
  6. 6. Archer SL, et al. Phosphodiesterase type 5 inhibitors in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009. PubMed
  7. 7. Kloner RA. Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation. 2004. PubMed
  8. 8. Jackson G, et al. Cardiovascular effects of tadalafil. Am J Cardiol. 2003. PubMed
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