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THYMOSIN ALPHA-1

THYMOSIN ALPHA-1

$60.00

Thymosin Alpha-1 Thymosin Alpha-1 is a synthetic acetylated 28-amino acid peptide originally isolated from thymic tissue. Preclinical studies in cell cultures and animal models indicate that Thymosin Alpha-1 enhances immune function by stimulating T-cell maturation, increasing cytokine production, and modulating innate and adaptive immune responses in various immunological challenge models.[1][2] Key Research Areas T-Cell Activation…

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Thymosin Alpha-1

Thymosin Alpha-1 is a synthetic acetylated 28-amino acid peptide originally isolated from thymic tissue. Preclinical studies in cell cultures and animal models indicate that Thymosin Alpha-1 enhances immune function by stimulating T-cell maturation, increasing cytokine production, and modulating innate and adaptive immune responses in various immunological challenge models.[1][2]

Key Research Areas

  • T-Cell Activation & Maturation – In rodent models of immunosuppression and viral infection, Thymosin Alpha-1 has been shown to promote T-cell differentiation, increase CD4+ and CD8+ cell counts, and enhance thymic output in aging or thymectomized animals.[3][4]
  • Antiviral & Antimicrobial Defense – Preclinical investigations demonstrate Thymosin Alpha-1 improves resistance to viral pathogens (e.g., influenza, hepatitis models) by upregulating interferon-γ, IL-2, and NK cell activity in infected animal models.[5][6]
  • Immune Modulation & Inflammatory Regulation – Animal studies suggest Thymosin Alpha-1 balances pro- and anti-inflammatory cytokines, reduces excessive inflammation in sepsis or autoimmune models, and supports immune homeostasis under stress conditions.[7][8]

Product Specifications

CAS Number 62304-98-7
Molecular Formula C129H215N37O55
Molar Mass 3108.32 g/mol
Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
Synonyms Thymalfasin, Zadaxin (brand name), TA-1
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage −20°C (long-term), 2–8°C (reconstituted)
Solubility Bacteriostatic water or sterile saline for reconstitution

References

  1. 1. Goldstein AL, et al. Thymosin alpha1: past, present and future. Ann N Y Acad Sci. 2005. PubMed
  2. 2. Matteucci C, et al. Thymosin alpha 1: A comprehensive review of the literature. World J Virol. 2017. PubMed
  3. 3. Baumann CA, et al. Thymosin alpha1 stimulates T-cell maturation in aged mice. Mech Ageing Dev. 1997. PubMed
  4. 4. Tuthill C, et al. Thymosin alpha1 effects on T-cell subsets in normal and immunosuppressed animals. Ann N Y Acad Sci. 2000. PubMed
  5. 5. Hadden JW, et al. Thymosin alpha1 enhances immune responses to influenza virus in mice. Int J Immunopharmacol. 1990. PubMed
  6. 6. Romani L, et al. Thymosin alpha1 enhances immune responses to hepatitis B vaccine in mice. Vaccine. 1995. PubMed
  7. 7. Matteucci C, et al. Thymosin alpha 1 reduces cytokine storm in sepsis models. Int Immunopharmacol. 2019. PubMed
  8. 8. Tuthill C, et al. Thymosin alpha1 in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002. (Immune modulation data)
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